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Pepsin A, powder

Pepsin is an acid protease. Its inactive zymogen precursor, pepsinogen, is produced in the stomach mucosa. There are several pepsins designated A, B, C, and D. Pepsin A, the major component, has a molecular weight of 35,000 daltons and an optimum pH for enzymatic activity of approximately 1.0 for substrates such as casein or hemoglobin if the substrate is native protein. Pepsin cleaves proteins preferentially at the carboxylic groups of aromatic amino acids such as phenylalanine and tyrosine. It will not cleave at bonds containing valine, alanine, or glycine. Pepsinogen activates to pepsin below pH 5. Pepsin is unstable above pH 6.

Source: Porcine stomach
2X crystallized from dilute alcohol; lyophilized powder
Activity: 2,500 units per mg dry weight
One unit releases 0.001 A280 as TCA soluble hydrolysis products per minute at 37C using denatured hemoglobin substrate.

Technical Information

• SDS - Pepsin A, powder
Catalog No. Size Price Lot # QTY
I59101 1 gm 285.00
I59190 10 gm 1100.00
Enter Lot # if you require a specific lot, otherwise leave blank. 

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